UJI AKTIVITAS ANTIBAKTERI HIDROGEL BASED DRESSING EKSTRAK IKAN GABUS (Channa striata) TERHADAP BAKTERI Staphylococcus aureus DAN Stapyhlococcus epidermis

Basse Yuliana; Oktaviana Ratnasari  Nggoweng

doi:10.59060/tbew9y75

Authors

Basse Yuliana Universitas Megarezky
Oktaviana Ratnasari Nggoweng Megarezky University

DOI:

https://doi.org/10.59060/tbew9y75

Keywords:

Ikan gabus, Hydrogel based dressing, Staphylococcus aureus, Staphylococcus epidermidis

Abstract

Snakehead fish (Channa striata) extract contains peptide compounds with antibacterial properties, making it a potential active ingredient for the development of hydrogel-based wound dressings. Hydrogel-based dressings are water-based wound dressings composed primarily of carboxymethyl cellulose (CMC), a hydrophilic polymer modified to absorb large amounts of water, along with additives such as polyethylene oxide or propylene glycol, which help maintain a moist wound environment. This study aimed to evaluate the antibacterial activity of hydrogel-based dressings containing snakehead fish (Channa striata) extract against the growth of Staphylococcus aureus and Staphylococcus epidermidis. The study employed an experimental method using the agar well diffusion technique. The results showed that against Staphylococcus aureus, hydrogel formulations containing 5%, 10%, and 15% extract produced inhibition zones of 2,96 mm, 4,76 mm, and 6,57 mm, respectively. Against Staphylococcus epidermidis, the inhibition zones were 2,95 mm, 4,87 mm, and 7,39 mm for the 5%, 10%, and 15% extract concentrations, respectively. It can be concluded that hydrogel-based dressings containing snakehead fish (Channa striata) extract exhibit antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis.

References

Achmad, H., Thahir, H., Rieuwpassa, I., Mardiana, A. A., Oktawati, S., Samad, R., Djais, A. I., Gani, A., Singgih, M. F., Madjid, F., & Admy, S. C. (2020) The Effectiveness Of Channa Striata Extract Antimicrobial Effect On Periopathogen Bacteria (Porphyromonas Gingivalis And Aggregatibacter Actinomycetemcomitans). Systematic Reviews In Pharmacy, 11(4), 319–323. Https://Doi.Org/10.31838/Srp.2020.4.46.

Aloanis A. A dan Vlagia I. P (2025). Peptida Antimikroba. Penerbit Tahta Media Group (Grup Penerbitan Cv Tahta Media Group

Apriani, A., & Fathir, A. (2021). Daya Hambat Getah Lidah Buaya (Aloe Vera) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus. Jurnal Sehat Indonesia (JUSINDO), 3(2), 40–48. Https://Doi.Org/10.36418/Jsi.V3i2.28

Aulya F, Erindyah R. W, Juwita R. (2025). Optimasi Formulasi Sediaan Nanoemulgel Minyak Nyamplung (Calophyllum inophyllum L.) Sebagai Anti Jerawat Dengan Uji Antibakteri Secara In Vitro. Optimization Of Nanoemulgel Formulation Of Nyamplung Oil (Calophyllum Inophyllum L.) As An Anti-Acne Agent Through In Vitro Antibacterial Testing. Journal of Pharmacy. Vol. 4, No. 4. https://jsr.lib.ums.ac.id/index.php/ujp

Azizah M , Lara S. L, Yopi R (2020). Uji aktivitas antibakteri kombinasi ekstrak etanol daun seledri (Apium graviolens L.) dan madu hutan terhadap beberapa bakteri penyebab penyakit kulit. Jurnal Penelitian Sains, Volume 22 (1). DOI: https://doi.org/10.26554/jps.v22i1.547

Edy, H. J., Marchaban, M., Wahyuono, S., & Nugroho, A. E. (2018). Pengujian Aktivitas Antibakteri Hidrogel Ekstrak Etanol Daun Tagetes erecta L. Jurnal MIPA, 8(3), 96.

Fitri, W., Sembiring, E., & Sembiring, A. W. (2019). Kesehatan Dan Ilmu (Sandoricum Koetjape Merr ) Terhadap Pertumbuhan Bakteri Jurnal Teknologi , Kesehatan Dan Ilmu Sosial. 1(1).

Haryani T. S, Salsabela, Cecep S, Euis N. (2023). Uji Proksimat dan Efektivitas Tape Hanjeli Sebagai Antibakteri Staphylococcus aureus Penyebab Penyakit Kulit. Prosiding Seminar Nasional Sains Dan Terapan (Semnas-Sinta). Volume 1, hal. 49 – 55

Li X, Siyao Z, Bin W, Kaiyu Z, and Yang W (2022). Antimicrobial Mechanisms and Clinical Application Prospects of Antimicrobial Peptides. Molecules, 27, 2675. https:// doi.org/10.3390/molecules27092675

Liu, J., Jiang, W., Xu, Q., & Zheng, Y. (2022). Progress In Antibacterial Hydrogel Dressing. Gels, 8(8). Https://Doi.Org/10.3390/Gels8080503

Ngelu, F. Y., Marbun, F. D., Sihombing, A. M., Manalu, Y., Ate, V. R. K. M., & Riswanto, F. D. O. (2022). Potensi Ekstrak Seledri (Apium Graveolens L) Sebagai Antibakteri. Jurnal Jamu Kusuma, 2(1), 23–29. Https://Doi.Org/10.37341/Jurnaljamukusuma.V2i1.22

Puspasari H , Suhaimi, Husnani , Isnia F. K. (2020). Uji Daya Hambat Ekstrak Kental Daun Kratom (Mitragyna Speciosa Korth) Terhadap Pertumbuhan Bakteri Staphylococcus pidermidis Sebagaipenyebab Jerawat The Treatment Of Potential Leaf Extract Of Kratom Leaf (Mitragyna Speciosa Korth) On The Growth Of Bacteriastaphylococcus Epidermidis Asacne Causes. Medical Sains Vol. 4 No.2

Sari, D. E., Novi, C. P., & Pujiati. (2016). UJi Aktivitas Antibakteri Tepung Ikan Gabus (Channa Striata) Terhadap Bakteri Patogen Pangan. Life Science, 5(1), 18–24. Http://Journal.Unnes.Ac.Id/Sju/Index.Php/Lifesci

Sari, S. I., Andas, A. M., & Wada, F. H. (2022). Efektivitas Hidrogel Terhadap Penyembuhan Luka Pada Pasien Pressure Ulcer. Jurnal Ilmiah Keperawatan IMELDA, 8(1), 52–57. Https://Doi.Org/10.52943/Jikeperawatan.V8i1.688

Sita Udayanti, & Rini Noviyani. (2023). Pemanfaatan Ekstrak Ikan Gabus (Channa Striata) Untuk Penyembuh Luka Pada Pasien Diabetes Mellitus (Ulkus Diabetikum). Prosiding Workshop Dan Seminar Nasional Farmasi, 1, 50–61. Https://Doi.Org/10.24843/Wsnf.2022.V01.I01.P05

Suhenro, Muhammad A. A. S, Prayitno S, Syaifullah S, Mifta K. I, Tamzil A. M (2024). Uji Aktivitas Serum Ekstrak Kulit Bawang Merah (Allium cepa L.) Terhadap Bakteri Propionibacterium acnes. Activity Test of Serum Extract Red Onion Skin (Allium cepa L.) Against Propionibacterium acnes Bacteria. Jurnal Promotif Preventif Vol. 7, No. 3. http://journal.unpacti.ac.id/index.php/JPP

Tethool, A. M., Tulandi, S. S., Tulandi, H. V., Paat, V. I., & Potalangi, N. O. (2021). Pengaruh Daya Hambat Sediaan Salep Ekstrak Daun Katuk (Sauropus Androgynus L.) Terhadap Pertumbuhan Bakteri Staphylococcus Aureus. Biofarmasetikal Tropis, 4(2), 33–38. Https://Doi.Org/10.55724/J.Biofar.Trop.V4i2.356

Wulandari dan Lilies Wahyu Ariyani (2020). Nanogel Minyak Biji Bunga Matahari (Helianthus annuus) Sebagai Antibakteri Terhadap Bakteri Staphylococcus aureus.

Yuliana, B., Sartini, Djabir, Y. Y., Permana, A. D., Aswad, M., Manggau, M. A., & Fawwaz, M. (2025). Formulation And Evaluation Of Snakehead Fish Mucus Emulgel For Enhanced Wound Healing And Antibacterial Activity. Letters In Applied Nanobioscience, 14(3), 1–10. Https://Doi.Org/10.33263/Lianbs143.147