UJI EFEKTIVITAS ANTIBAKTERI SEDIAAN GEL EKSTRAK DAUN MELINJO (Gnetum gnemon L) TERHADAP BAKTERI Staphylococcus aureus

Rizka Anggreani; Esti Febri Fatwami; Dian Islamiyati

doi:10.59060/tnvdrp59

Authors

Rizka Anggreani Stikes Bina Cipta Husada Purwokerto
Esti Febri Fatwami D3 Farmasi STIKes Bina Cipta Husada Purwokerto
Dian Islamiyati Stikes Bina Cipta Husada Purwokerto

DOI:

https://doi.org/10.59060/tnvdrp59

Keywords:

Melinjo (Gnetum gnemon L.), Ekstrak, Gel, Aktivias antibakteri

Abstract

This study aimed to evaluate the antibacterial activity of Gnetum gnemon L. leaf extract gel against Staphylococcus aureus. The leaf extract was obtained through the maceration method using 96% ethanol as the extraction solvent. Gel formulations containing G. gnemon leaf extract at concentrations of 5%, 7%, and 9% were subsequently prepared and evaluated for their antibacterial activity. The antibacterial assay was performed using the disc diffusion method on Nutrient Agar (NA) inoculated with S. aureus. Chloramphenicol was used as the positive control, while the gel base served as the negative control. The results demonstrated that all gel formulations containing G. gnemon leaf extract exhibited inhibitory activity against the growth of S. aureus. Among the tested formulations, the 9% extract gel showed the highest antibacterial activity, producing a mean inhibition zone diameter of 16.5 mm, which was classified as a strong inhibitory effect. These findings indicate that G. gnemon leaf extract gel, particularly at a concentration of 9%, has promising potential as a topical antibacterial agent against Staphylococcus aureus.

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