UJI AKTIVITAS ANTIBAKTERI KRIM EKSTRAK HERBA PEGAGAN ( Centella asiatica (L.) Urban) Terhadap  Propionibacterium acne

sukirawati sukirawati; Habiba Syafitri Khouw

doi:10.59060/jurkes.v7i1.269

sukirawati sukirawati akademi farmasi yamasi makassar
Habiba Syafitri Khouw Akademi Farmasi Yamasi Makassar

DOI: https://doi.org/10.59060/jurkes.v7i1.269

Abstract

The aim of this study was to test the inhibitory effect of the Herba Pegagan (Centella asiatica (L.) Urban.) extract against Propionibacterium acnes. The research design used was an experimental laboratory by conducting an experiment to observe how much inhibition the cream preparation had against Propionibacterium acnes which was carried out at the microbiology laboratory of the Yamasi Pharmacy Academy Makassar. Pegagan Herba (Centella asiatica (L.) Urban.) was extracted by maceration with 96% ethanol as solvent. Pegagan Herba Extract is made in 5% and 10% concentrations. The inhibition zone was determined using the well method and Nutrient Agar (NA) as a medium with an incubation period of 1 x 24 hours at 37ºC. The results of the study with an average inhibition diameter of 5% concentration was 17.3 mm, 10% concentration was 11 mm

References

Allen, L.V. (1998). The Art Science and Technology of harmaceutical Compounding. Washington, DC: American Pharmaceutical Assosiaton.

Badan POM RI. (2016). Serial Data Ilmiah Terkini Tumbuhan Obat Pegagan (Centella asiatica (L.) Urban. Jakarta: Badan POM RI.

Budi, S., & Rahmawati, M. (2019). Pengembangan Formula Gel Ekstrak Pegagan (Centella asiatica (L.) Urb) sebagai anti jerawat. Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 6(2), 51-55.

Cunliffe WJ dan Gollnick HPM. (2001). Clinical features of acne. In : Cunliffe WJ, Gollnick HPM. Acne Diagnosis and Management. London: Martin Dunitz Ltd : 49-68.

Hastuti, N. S., Taurhesia, S., & Wibowo, A. E. (2017). Aktivitas secara in vitro dan in vivo kombinasi ekstrak daun kelor (Moringa oleifera lam.) dan pegagan (Centella asiatica (L.). Urb) sebagai gel anti jerawat. Majalah farmasi.

Jain, A., Sangal, L., Basal, E., Kaushal, G. P., Agarwal, S. K. (2002). Anti-inflammatory effect of erythromycin and tetracycline on Propionibacterium acnes induced production of chemotatic factors and reactive oxygen species by huan neutrophils. Dermatology Online Journal 8 (2): 1-10.

Jawetz, Melnick dan Adelberg. (2007). Medical Microbiology. Edisi 24. United State. Mc-graw Hill Companies.

Riskawati Ointu, (2018). Uji Aktivitas Ekstrak Daun Pegagan (Centella asiatica (L.) Urban). Terhadap Bakteri Propionibacterium acnes. Karya Tulis Ilmiah. Program Studi D3-Farmasi. Jurusan Farmasi, Fakultas Olahraga dan Kesehatan, Universitas Negeri Gorontalo.

Sikareepaisan, P., Suksamrarn, A. & Supaphol, P. (2008). Electrospun Gelatin Fiber Mats Containing A Herbal Centella asiatica Extract and Release Characteristic of Asiaticoside. Nanotechnology; 19; 1-10.

Soebagio, T. T., Hartini, Y. S., & Mursyanti, E. (2020). Aktivitas Antibakteri Sediaan Sabun Wajah Cair Ekstrak Herba Pegagan (Centella asiatica (L.) Urban) terhadap Pertumbuhan Stapylococcus aureus dan Propionibacterium acnes. Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati, 5(2), 69-80.

Tranggono, R.I. (2007): Buku Pegangan Ilmu Pengetahuan Kosmtik. Jakarta: PT. Gramedia Pustaka Utama.