PEMANFAATAN LIMBAH KULIT BUAH SALAK PONDOH (Salaccae edulis Reinw) MENJADI SEDIAAN SAMPO DAN AKTIVITASNYA TERHADAP Staphylococcus epidermidis DAN Candida albicans

  • Yuyun Sri Wahyuni
  • Hernawati Basir Universitas Muhammadiyah Makassar
  • Riskayanti Puspita Sari Akademi Farmasi Yamasi Makassar
  • Asamaul Husna Akademi Farmasi Yamasi Makassar

Abstract

In South Sulawesi Province, the pondoh salak plant is widely used as medicine. Many people only eat the fruit and throw away the skin, because they consider the skin of the Pondoh salak fruit to be useless. Pondoh salak fruit skin contains flavonoids, saponins, tannins, phenols, terpenoids and alkaloids. The saponin content functions as a foam maker and flavonoids function to accelerate hair growth. This research aims to make a shampoo preparation from the ethanol extract of Pondoh salak fruit peel (Salacca edulis Reinw) and test the stability of the shampoo and test the activity of the shampoo preparation of Pondoh salak fruit peel ethanol extract (Salacca edulis Reinw) on the growth of Staphylococcus epidermidis and Candida albicans. This research used laboratory experimental methods, formulating shampoo from ethanol extract of pondoh salak fruit peel (Salacca edulis Reinw) into four formulations with respective concentrations, namely F0: 0%, F1: 10%, F2: 15% and F3: 20%. The physical stability test of the ethanol extract shampoo preparation of pondoh salak fruit peel (Salacca edulis Reinw) includes organoleptic test, homogeneity test, pH test, foam power test, viscosity test, free alkali test and storage stability test. Free alkali test results show that all formulations contain alkali. Storage stability test results for 6 cycles or 12 days at temperature 4OC and 40OC all dosage formulations remain stable. The results of the organoleptic test and homogeneity test remained stable, for the pH test and foam power there was a decrease and for the viscosity test there was an increase after the cycling test was carried out but it still met SNI requirements. Meanwhile, in testing the activity of Staphylococcus epidermidis in F1 10% the resulting inhibitory zone area was an average of 32.93 mm, in F2 15% the resulting inhibitory zone area was 28.56 mm, and in F3 20% the resulting inhibitory zone area was 20.93mm. Meanwhile, in the Candida albicans test, F1 10% inhibitory zone area averaged 24.61 mm, F2 15% average inhibitory zone area 25.94 mm, F3 inhibitory zone area 19.44 mm. Based on the results of the research that has been carried out, it can be concluded that the ethanol extract of pondoh salak fruit peel (Salacca edulis Reinw) meets the requirements of the physical stability test and can inhibit the growth of Staphylococcus epidermidis. The three inhibitory power measurements of each formulation are categorized as having a very strong inhibition zone area, while the activity testing for Candida Albicans F1 and F2 has a very strong zone of inhibition. very strong inhibition while F3 has a strong inhibition zone.

References

Adjeng, A.N.T. et al. (2020) ‘Skrining fitokimia dan evaluasi sediaan sabun cair ekstrak etanol 96% kulit buah salak pondoh (Salacca zalacca (Gaertn.) Voss.) sebagai antioksidan’, Pharmauho J Farm Sains, dan Kesehat, 5(2), pp. 3–6.
Allen L.V (2009) Handbook of Pharmaceutical Excipients. Sixth Edit, Royal Pharmaceutical Society of Great Britain. Sixth Edit. Edited by M.E.Q. Raymond C Rowe, Paul J Sheskey. London. Available at: https://doi.org/10.1016/B978-0-12-820007-0.00032-5.
Erwiyani, A.R. et al. (2023) ‘Formulasi dan Evaluasi Sampo Ekstrak Labu Kuning (Cucurbita maxima D.)’, Majalah Farmasetika, 8(2). Available at: https://doi.org/10.24198/mfarmasetika.v8i2.43686.
Jusnita, N. and Syah, R.A. (2017) ‘Formulasi dan Uji Stabilitas Fisik Sediaan Shampo Dari Ekstrak Etanol Daun Pare (Momordica charantia Linn.)’, Indonesia Natural Research Pharmaceutical Journal, 2(1), pp. 24–39.
Maulana, I.A., Triatmoko, B. and Nugraha, A.S. (2020) ‘Skrining Fitokimia dan Uji Aktivitas Antibakteri Ekstrak dan Fraksi Tanaman Senggugu (Rotheca serrata (L.) Steane & Mabb.) terhadap Pseudomonas aeruginosa’, JPSCR: Journal of Pharmaceutical Science and Clinical Research, 5(1), p. 01. Available at: https://doi.org/10.20961/jpscr.v5i1.32200.
Mitsui, T. (1997) ‘New Cosmetc Science. First Edition’, Elsevier Science B.V., pp. 13–21.
Nasional, B.S. (1992) Standar Mutu Sampo. SNI 06-2692-1992. Dewan Standarisasi Nasional. Jakarta.[In Indonesian].
Pertiwi, F.D., Rezaldi, F. and Puspitasari, R. (2022) ‘Uji Aktivitas Antibakteri Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) Terhadap Bakteri Staphylococcus epidermidis’, Biosaintropis (Bioscience-Tropic), 7(2), pp. 57–68. Available at: https://doi.org/10.33474/e-jbst.v7i2.471.
Sahputra, F.M. (2008) ‘Potensi ekstrak kulit dan daging buah salak sebagai antidiabetes’, Skripsi. FMIPA Institut Pertanian Bogor. Bogor [Preprint].
Salsabila, H.G., Zamruddin, N.M. and Herman, H. (2022) ‘Optimasi Konsentrasi Basis HPMC Sediaan Sampo Antiketombe Ekstrak Daun Belimbing Wuluh (Averrhoa bilimbi L.) Kombinasi Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb)’, Proceeding of Mulawarman Pharmaceuticals Conferences, 15, pp. 94–99. Available at: https://doi.org/10.25026/mpc.v15i1.624.
Saptowo, A., Supriningrum, R. and Supomo, S. (2022) ‘UJI AKTIVITAS ANTIBAKTERI EKSTRAK KULIT BATANG SEKILANG (Embeliaborneensis Scheff) TERHADAP BAKTERI Propionibacterium acnes dan Staphylococcus epidermidis’, Al-Ulum: Jurnal Sains Dan Teknologi, 7(2), p. 93. Available at: https://doi.org/10.31602/ajst.v7i2.6331.
Shabir, E.S. et al. (2018) ‘Uji fitokimia ekstrak kulit buah salak (Salacca zalacca) dan pengaruh ekstrak terhadap pertumbuhan bakteri Streptococcus mutans dan jamur Candida albicans’, in Proceeding of Mulawarman Pharmaceuticals Conferences, pp. 314–320.
SNI (1992) Sni 06-2692-1992 Shampoo. Jakarta: Dewan Standarisasi Nasional.
Voight, R. (1994) Pharmacy Technology Textbooks. Ed.
Published
2024-02-16